Hypercapnia Exacerbates the Blood–Brain Barrier Disruption Via Promoting HIF-1a Nuclear Translocation in the Astrocytes of the Hippocampus: Implication in Further Cognitive Impairment in Hypoxemic Adult Rats

Hypercapnia in combination with hypoxemia is usually present in severe respiratory disease in the intensive care unit (ICU) and can lead to more severe cognitive dysfunction. Increasing evidence has indicated that the compromised blood–brain barrier (BBB) in the hippocampus in hypoxemia conditions c...

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Bibliographic Details
Published in:Neurochem Res
Main Authors: Liu, Xinqiang, Ding, Hongguang, Li, Xusheng, Deng, Yiyu, Liu, Xiaoyu, Wang, Kangrong, Wen, Miaoyun, Chen, Shenglong, Jiang, Wenqiang, Zeng, Hongke
Format: Artigo
Language:Inglês
Published: Springer US 2020
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7224048/
https://ncbi.nlm.nih.gov/pubmed/32328929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-020-03038-7
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