Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway

Mannose-binding lectin (MBL)-associated serine protease-2 (MASP-2) is an indispensable enzyme for the activation of the lectin pathway of complement. Its deficiency is classified as a primary immunodeficiency associated to pyogenic bacterial infections, inflammatory lung disease, and autoimmunity. I...

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Bibliografske podrobnosti
izdano v:J Clin Immunol
Main Authors: García-Laorden, M. Isabel, Hernández-Brito, Elisa, Muñoz-Almagro, Carmen, Pavlovic-Nesic, Svetlana, Rúa-Figueroa, Iñigo, Briones, M. Luisa, Rajas, Olga, Borderías, Luis, Payeras, Antoni, Lorente, Leonardo, Freixinet, Jordi, Ferreres, Jose, Obando, Ignacio, González-Quevedo, Nereida, Rodríguez de Castro, Felipe, Solé-Violán, Jordi, Rodríguez-Gallego, Carlos
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2019
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7223972/
https://ncbi.nlm.nih.gov/pubmed/31828694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10875-019-00714-4
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