MicroRNA-421-3p-abundant small extracellular vesicles derived from M2 bone marrow-derived macrophages attenuate apoptosis and promote motor function recovery via inhibition of mTOR in spinal cord injury

BACKGROUND: Spinal cord injury (SCI) has a very disabling central nervous system impact but currently lacks effective treatment. Bone marrow-derived macrophages (BMDMs) are recruited to the injured area after SCI and participate in the regulation of functional recovery with microglia. Previous studi...

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Publicat a:J Nanobiotechnology
Autors principals: Wang, Jiaxing, Rong, Yuluo, Ji, Chengyue, Lv, Chengtang, Jiang, Dongdong, Ge, Xuhui, Gong, Fangyi, Tang, Pengyu, Cai, Weihua, Liu, Wei, Fan, Jin
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7222346/
https://ncbi.nlm.nih.gov/pubmed/32404105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-020-00630-5
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