Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

Cardiac myosin binding protein-C (cMyBP-C) phosphorylation is essential for normal heart function and protects the heart from ischemia-reperfusion (I/R) injury. It is known that protein kinase-A (PKA)-mediated phosphorylation of cMyBP-C prevents I/R-dependent proteolysis, whereas dephosphorylation o...

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Bibliografski detalji
Izdano u:J Mol Cell Cardiol
Glavni autori: Barefield, David Y., McNamara, James W., Lynch, Thomas L., Kuster, Diederik W. D., Govindan, Suresh, Haar, Lauren, Wang, Yang, Taylor, Erik N., Lorenz, John N., Nieman, Michelle L., Zhu, Guangshuo, Luther, Pradeep K., Varró, Andras, Dobrev, Dobromir, Ai, Xun, Janssen, Paul M.L., Kass, David A., Jones, Walter Keith, Gilbert, Richard J., Sadayappan, Sakthivel
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7222036/
https://ncbi.nlm.nih.gov/pubmed/30862451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.03.006
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