Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-ij]Quinolin-2(1H)-one as New Inhibitors of Factor Xa and Factor XIa

Coagulation factor Xa and factor XIa are proven to be convenient and crucial protein targets for treatment for thrombotic disorders and thereby their inhibitors can serve as effective anticoagulant drugs. In the present work, we focused on the structure–activity relationships of derivatives of pyrro...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Molecules
Prif Awduron: Novichikhina, Nadezhda, Ilin, Ivan, Tashchilova, Anna, Sulimov, Alexey, Kutov, Danil, Ledenyova, Irina, Krysin, Mikhail, Shikhaliev, Khidmet, Gantseva, Anna, Gantseva, Ekaterina, Podoplelova, Nadezhda, Sulimov, Vladimir
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7222003/
https://ncbi.nlm.nih.gov/pubmed/32325823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25081889
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