LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages

The Parkinson's disease-associated gene, LRRK2, is also associated with immune disorders and infectious disease and is expressed in immune subsets. Here, we characterize a platform for interrogating the expression and function of endogenous LRRK2 in authentic human phagocytes using human induce...

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Pubblicato in:Stem Cell Reports
Autori principali: Lee, Heyne, Flynn, Rowan, Sharma, Ishta, Haberman, Emma, Carling, Phillippa J., Nicholls, Francesca J., Stegmann, Monika, Vowles, Jane, Haenseler, Walther, Wade-Martins, Richard, James, William S., Cowley, Sally A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221108/
https://ncbi.nlm.nih.gov/pubmed/32359446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.04.001
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