Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons

Hereditary spastic paraplegia (HSP) is a group of inherited disorders characterized by progressive spasticity and paralysis of the lower limbs. Autosomal dominant mutations in SPAST gene account for ∼40% of adult-onset patients. We have previously shown that SPAST patient cells have reduced organell...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Front Neurosci
Auteurs principaux: Wali, Gautam, Liyanage, Erandhi, Blair, Nicholas F., Sutharsan, Ratneswary, Park, Jin-Sung, Mackay-Sim, Alan, Sue, Carolyn M.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221066/
https://ncbi.nlm.nih.gov/pubmed/32457567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00401
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires