Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons

Hereditary spastic paraplegia (HSP) is a group of inherited disorders characterized by progressive spasticity and paralysis of the lower limbs. Autosomal dominant mutations in SPAST gene account for ∼40% of adult-onset patients. We have previously shown that SPAST patient cells have reduced organell...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Wali, Gautam, Liyanage, Erandhi, Blair, Nicholas F., Sutharsan, Ratneswary, Park, Jin-Sung, Mackay-Sim, Alan, Sue, Carolyn M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221066/
https://ncbi.nlm.nih.gov/pubmed/32457567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00401
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