Poly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond

Genetic complexity and DNA damage repair defects are common in different cancer types and can induce tumor-specific vulnerabilities. Poly(ADP-ribose) polymerase (PARP) inhibitors exploit defects in the DNA repair pathway through synthetic lethality and have emerged as promising anticancer therapies,...

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Опубликовано в: :Drugs R D
Главные авторы: Boussios, Stergios, Abson, Charlotte, Moschetta, Michele, Rassy, Elie, Karathanasi, Afroditi, Bhat, Tahir, Ghumman, Faisal, Sheriff, Matin, Pavlidis, Nicholas
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2020
Предметы:
Review Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7221042/
https://ncbi.nlm.nih.gov/pubmed/32215876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40268-020-00301-8
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