HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) parallels the global obesity epidemic with unmet therapeutic needs. We investigated whether inhibition of hypoxia-inducible factor prolyl 4-hydroxylase-2 (HIF-P4H-2), a key cellular oxygen sensor whose inhibition stabilizes HIF, would protect from...

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Detalhes bibliográficos
Publicado no:J Mol Med (Berl)
Main Authors: Laitakari, Anna, Tapio, Joona, Mäkelä, Kari A., Herzig, Karl-Heinz, Dengler, Franziska, Gylling, Helena, Walkinshaw, Gail, Myllyharju, Johanna, Dimova, Elitsa Y., Serpi, Raisa, Koivunen, Peppi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220983/
https://ncbi.nlm.nih.gov/pubmed/32296880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-020-01903-0
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