Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer

Branched-chain α-keto acid dehydrogenase kinase (BCKDK), the key enzyme of branched-chain amino acids (BCAAs) metabolism, has been reported to promote colorectal cancer (CRC) tumorigenesis by upregulating the MEK-ERK signaling pathway. However, the profile of BCKDK in metastatic colorectal cancer (m...

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Udgivet i:Oncogene
Main Authors: Tian, Qin, Yuan, Ping, Quan, Chuntao, Li, Mingyang, Xiao, Juanjuan, Zhang, Lu, Lu, Hui, Ma, Tengfei, Zou, Ling, Wang, Fei, Xue, Peipei, Ni, Xiaofang, Wang, Wei, Liu, Lin, Wang, Zhe, Zhu, Feng, Duan, Qiuhong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7220852/
https://ncbi.nlm.nih.gov/pubmed/32238881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1262-z
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