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Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry
This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library...
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| Udgivet i: | Chem Commun (Camb) |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7218690/ https://ncbi.nlm.nih.gov/pubmed/32104839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc00266f |
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