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Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library...

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Bibliografski detalji
Izdano u:Chem Commun (Camb)
Glavni autori: Juru, Aline Umuhire, Cai, Zhengguo, Jan, Adina, Hargrove, Amanda E.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218690/
https://ncbi.nlm.nih.gov/pubmed/32104839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc00266f
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