A luminal unfolding microneedle injector for oral delivery of macromolecules

Insulin and other injectable biologic drugs have transformed the treatment of patients suffering from diabetes. Patients and healthcare providers, however, prefer the oral route of administration, yet macromolecule drugs are not readily absorbed into the bloodstream through the gastrointestinal trac...

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Pubblicato in:Nat Med
Autori principali: Abramson, Alex, Caffarel-Salvador, Ester, Soares, Vance, Minahan, Daniel, Tian, Ryan Yu, Lu, Xiaoya, Dellal, David, Gao, Yuan, Kim, Soyoung, Wainer, Jacob, Collins, Joy, Tamang, Siddartha, Hayward, Alison, Yoshitake, Tadayuki, Lee, Hsiang-Chieh, Fujimoto, James, Fels, Johannes, Frederiksen, Morten Revsgaard, Rahbek, Ulrik, Roxhed, Niclas, Langer, Robert, Traverso, Giovanni
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218658/
https://ncbi.nlm.nih.gov/pubmed/31591601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0598-9
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