Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration

Analysis of isolated meninges and cerebrospinal fluid (CSF) of post-mortem MS cases has shown increased gene and protein expression for the pro-inflammatory cytokines: tumour necrosis factor (TNF) and interferon-γ (IFNγ). Here we tested the hypothesis that persistent production of these cytokines in...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: James, Rachel E., Schalks, Renee, Browne, Eleanor, Eleftheriadou, Ioanna, Munoz, Carmen Picon, Mazarakis, Nicholas D., Reynolds, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218553/
https://ncbi.nlm.nih.gov/pubmed/32398070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00938-1
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