CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model

BACKGROUND: Anti-tumor effects of radiation therapy (RT) largely depend on host immune function. Adenosine with its strong immunosuppressive properties is an important immune checkpoint molecule. METHOD: We examined how intra-tumoral adenosine levels modify anti-tumor effects of RT in a murine model...

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Bibliografiske detaljer
Udgivet i:BMC Cancer
Main Authors: Tsukui, Hidenori, Horie, Hisanaga, Koinuma, Koji, Ohzawa, Hideyuki, Sakuma, Yasunaru, Hosoya, Yoshinori, Yamaguchi, Hironori, Yoshimura, Kotaro, Lefor, Alan Kawarai, Sata, Naohiro, Kitayama, Joji
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218548/
https://ncbi.nlm.nih.gov/pubmed/32397971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-06893-3
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