Comparative Analysis of Thymic and Blood Treg in Myasthenia Gravis: Thymic Epithelial Cells Contribute to Thymic Immunoregulatory Defects

The thymus is involved in autoimmune Myasthenia gravis (MG) associated with anti-acetylcholine (AChR) antibodies. In MG, thymic regulatory T cells (Treg) are not efficiently suppressive, and conventional T cells (Tconv) are resistant to suppression. To better understand the specific role of the thym...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Truffault, Frédérique, Nazzal, Dani, Verdier, Julien, Gradolatto, Angeline, Fadel, Elie, Roussin, Régine, Eymard, Bruno, Le Panse, Rozen, Berrih-Aknin, Sonia
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218102/
https://ncbi.nlm.nih.gov/pubmed/32435245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00782
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