ACLY is the novel signaling target of PIP(2)/PIP(3) and Lyn in acute myeloid leukemia

A fundamental feature of tumor progression is reprogramming of metabolic pathways. ATP citrate lyase (ACLY) is a key metabolic enzyme that catalyzes the generation of Acetyl-CoA and is upregulated in cancer cells and required for their growth. The phosphoinositide 3-kinase (PI3K) and Src-family kina...

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Vydáno v:Heliyon
Hlavní autoři: Basappa, Johnvesly, Citir, Mevlut, Zhang, Qian, Wang, Hong Y., Liu, Xiaobin, Melnikov, Olga, Yahya, Hafiz, Stein, Frank, Muller, Rainer, Traynor-Kaplan, Alexis, Schultz, Carsten, Wasik, Mariusz A., Ptasznik, Andrzej
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218026/
https://ncbi.nlm.nih.gov/pubmed/32420483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2020.e03910
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