Chronic Activation of Gp1 mGluRs Leads to Distinct Refinement of Neural Network Activity through Non-Canonical p53 and Akt Signaling

Group 1 metabotropic glutamate receptors (Gp1 mGluRs), including mGluR1 and mGluR5, are critical regulators for neuronal and synaptic plasticity. Dysregulated Gp1 mGluR signaling is observed with various neurologic disorders, including Alzheimer’s disease, Parkinson’s disease, epilepsy, and autism s...

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Pubblicato in:eNeuro
Autori principali: Liu, Dai-Chi, Soriano, Stephanie, Yook, Yeeun, Lizarazo, Simon, Eagleman, Daphne E., Tsai, Nien-Pei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2020
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Research Article: New Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218008/
https://ncbi.nlm.nih.gov/pubmed/32161037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0438-19.2020
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