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EGFR Signaling Causes Morphine Tolerance and Mechanical Sensitization in Rats

The safety and efficacy of opioids are compromised as analgesic tolerance develops. Opioids are also ineffective against neuropathic pain. Recent reports have suggested that inhibitors of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), may have analgesic effects in can...

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Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Puig, Stephanie, Donica, Courtney L., Gutstein, Howard B.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7218007/
https://ncbi.nlm.nih.gov/pubmed/32111605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0460-18.2020
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