Detection of low-frequency resistance-mediating SNPs in next-generation sequencing data of Mycobacterium tuberculosis complex strains with binoSNP

Accurate drug resistance detection is key for guiding effective tuberculosis treatment. While genotypic resistance can be rapidly detected by molecular methods, their application is challenged by mixed mycobacterial populations comprising both susceptible and resistant cells (heteroresistance). For...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Dreyer, Viola, Utpatel, Christian, Kohl, Thomas A., Barilar, Ivan, Gröschel, Matthias I., Feuerriegel, Silke, Niemann, Stefan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217866/
https://ncbi.nlm.nih.gov/pubmed/32398743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64708-8
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