Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination

The bacterial effector MavC modulates the host immune response by blocking Ube2N activity employing an E1-independent ubiquitin ligation, catalyzing formation of a γ-glutamyl-ε-Lys (Gln40(Ub)-Lys92(Ube2N)) isopeptide crosslink using a transglutaminase mechanism. Here we provide biochemical evidence...

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Pubblicato in:Nat Commun
Autori principali: Puvar, Kedar, Iyer, Shalini, Fu, Jiaqi, Kenny, Sebastian, Negrón Terón, Kristos I., Luo, Zhao-Qing, Brzovic, Peter S., Klevit, Rachel E., Das, Chittaranjan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217864/
https://ncbi.nlm.nih.gov/pubmed/32398758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16211-x
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