A Population Pharmacokinetic Model Does Not Predict the Optimal Starting Dose of Tacrolimus in Pediatric Renal Transplant Recipients in a Prospective Study: Lessons Learned and Model Improvement

BACKGROUND AND OBJECTIVE: Bodyweight-based dosing of tacrolimus is considered standard care. Currently, at first steady state, a third of pediatric kidney transplant recipients has a tacrolimus pre-dose concentration within the target range. We investigated whether adaptation of the starting dose ac...

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Publicat a:Clin Pharmacokinet
Autors principals: Andrews, Louise M., de Winter, Brenda C. M., Cornelissen, Elisabeth A. M., de Jong, Huib, Hesselink, Dennis A., Schreuder, Michiel F., Brüggemann, Roger J. M., van Gelder, Teun, Cransberg, Karlien
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2019
Matèries:
Original Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217818/
https://ncbi.nlm.nih.gov/pubmed/31654367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-019-00831-8
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