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Dasatinib inhibits peripapillary scleral myofibroblast differentiation

Scleral fibroblast activation occurs in glaucomatous and myopic eyes. Here we perform an unbiased screen to identify kinase inhibitors that reduce fibroblast activation to diverse stimuli in vitro and to in vivo intraocular pressure (IOP) elevation. Primary cultures of peripapillary scleral (PPS) fi...

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Foilsithe in:Exp Eye Res
Main Authors: Chow, Amanda, McCrea, Liam, Kimball, Elizabeth, Schaub, Julie, Quigley, Harry, Pitha, Ian
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217736/
https://ncbi.nlm.nih.gov/pubmed/32179077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2020.107999
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