Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets

Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers of abnormal bone marrow megakaryocytes that induce fibrosis, destroying the hematopoietic microenvironment. To determine the cellular and molecular basis for aberrant megakaryopoiesis in myelofibrosis, we perfor...

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Vydáno v:Mol Cell
Hlavní autoři: Psaila, Bethan, Wang, Guanlin, Rodriguez-Meira, Alba, Li, Rong, Heuston, Elisabeth F., Murphy, Lauren, Yee, Daniel, Hitchcock, Ian S., Sousos, Nikolaos, O’Sullivan, Jennifer, Anderson, Stacie, Senis, Yotis A., Weinberg, Olga K., Calicchio, Monica L., Iskander, Deena, Royston, Daniel, Milojkovic, Dragana, Roberts, Irene, Bodine, David M., Thongjuea, Supat, Mead, Adam J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217381/
https://ncbi.nlm.nih.gov/pubmed/32386542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.04.008
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