Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets

Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers of abnormal bone marrow megakaryocytes that induce fibrosis, destroying the hematopoietic microenvironment. To determine the cellular and molecular basis for aberrant megakaryopoiesis in myelofibrosis, we perfor...

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Publicat a:Mol Cell
Autors principals: Psaila, Bethan, Wang, Guanlin, Rodriguez-Meira, Alba, Li, Rong, Heuston, Elisabeth F., Murphy, Lauren, Yee, Daniel, Hitchcock, Ian S., Sousos, Nikolaos, O’Sullivan, Jennifer, Anderson, Stacie, Senis, Yotis A., Weinberg, Olga K., Calicchio, Monica L., Iskander, Deena, Royston, Daniel, Milojkovic, Dragana, Roberts, Irene, Bodine, David M., Thongjuea, Supat, Mead, Adam J.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217381/
https://ncbi.nlm.nih.gov/pubmed/32386542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.04.008
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