A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein

SARS-CoV-2 is a zoonotic virus that has caused a pandemic of severe respiratory disease—COVID-19—within several months of its initial identification. Comparable to the first SARS-CoV, this novel coronavirus’s surface Spike (S) glycoprotein mediates cell entry via the human ACE-2 receptor, and, thus,...

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Publicado no:bioRxiv
Main Authors: Joyce, M. Gordon, Sankhala, Rajeshwer S., Chen, Wei-Hung, Choe, Misook, Bai, Hongjun, Hajduczki, Agnes, Yan, Lianying, Sterling, Spencer L., Peterson, Caroline E., Green, Ethan C., Smith, Clayton, de Val, Natalia, Amare, Mihret, Scott, Paul, Laing, Eric D., Broder, Christopher C., Rolland, Morgane, Michael, Nelson L., Modjarrad, Kayvon
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7217142/
https://ncbi.nlm.nih.gov/pubmed/32511298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.03.15.992883
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