Investigating the Causal Effect of Brain Expression of CCL2, NFKB1, MAPK14, TNFRSF1A, CXCL10 Genes on Multiple Sclerosis: A Two-Sample Mendelian Randomization Approach

Multiple Sclerosis (MS) exhibits considerable heterogeneity in phenotypic expression, course, prognosis and response to therapy. This suggests this disease involves multiple, as yet poorly understood, causal mechanisms. In this work we assessed the possible causal link between gene expression level...

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發表在:Front Bioeng Biotechnol
Main Authors: Fazia, Teresa, Nova, Andrea, Gentilini, Davide, Beecham, Ashley, Piras, Marialuisa, Saddi, Valeria, Ticca, Anna, Bitti, Pierpaolo, McCauley, Jacob L., Berzuini, Carlo, Bernardinelli, Luisa
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020
主題:
Bioengineering and Biotechnology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216783/
https://ncbi.nlm.nih.gov/pubmed/32432099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.00397
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