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Investigating the Causal Effect of Brain Expression of CCL2, NFKB1, MAPK14, TNFRSF1A, CXCL10 Genes on Multiple Sclerosis: A Two-Sample Mendelian Randomization Approach

Multiple Sclerosis (MS) exhibits considerable heterogeneity in phenotypic expression, course, prognosis and response to therapy. This suggests this disease involves multiple, as yet poorly understood, causal mechanisms. In this work we assessed the possible causal link between gene expression level...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Fazia, Teresa, Nova, Andrea, Gentilini, Davide, Beecham, Ashley, Piras, Marialuisa, Saddi, Valeria, Ticca, Anna, Bitti, Pierpaolo, McCauley, Jacob L., Berzuini, Carlo, Bernardinelli, Luisa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216783/
https://ncbi.nlm.nih.gov/pubmed/32432099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.00397
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