Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated

BACKGROUND: Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation. METHODS: DNA and RNA mutation status was assessed in 15 melanoma cell lines by Sanger...

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Vydáno v:J Transl Med
Hlavní autoři: Al Hashmi, Muna, Sastry, Konduru S., Silcock, Lee, Chouchane, Lotfi, Mattei, Valentina, James, Nicola, Mathew, Rebecca, Bedognetti, Davide, De Giorgi, Valeria, Murtas, Daniela, Liu, Wei, Chouchane, Aouatef, Temanni, Ramzi, Seliger, Barbara, Wang, Ena, Marincola, Francesco M., Tomei, Sara
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216681/
https://ncbi.nlm.nih.gov/pubmed/32393282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02350-8
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