Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated

BACKGROUND: Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation. METHODS: DNA and RNA mutation status was assessed in 15 melanoma cell lines by Sanger...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Al Hashmi, Muna, Sastry, Konduru S., Silcock, Lee, Chouchane, Lotfi, Mattei, Valentina, James, Nicola, Mathew, Rebecca, Bedognetti, Davide, De Giorgi, Valeria, Murtas, Daniela, Liu, Wei, Chouchane, Aouatef, Temanni, Ramzi, Seliger, Barbara, Wang, Ena, Marincola, Francesco M., Tomei, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7216681/
https://ncbi.nlm.nih.gov/pubmed/32393282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02350-8
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