“Mitotic Slippage” and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres

Mitotic slippage (MS), the incomplete mitosis that results in a doubled genome in interphase, is a typical response of TP53-mutant tumors resistant to genotoxic therapy. These polyploidized cells display premature senescence and sort the damaged DNA into the cytoplasm. In this study, we explored MS...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Salmina, Kristine, Bojko, Agnieszka, Inashkina, Inna, Staniak, Karolina, Dudkowska, Magdalena, Podlesniy, Petar, Rumnieks, Felikss, Vainshelbaum, Ninel M, Pjanova, Dace, Sikora, Ewa, Erenpreisa, Jekaterina
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7215480/
https://ncbi.nlm.nih.gov/pubmed/32316332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21082779
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