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Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers
Most cancers have lost a critical DNA damage response (DDR) pathway during tumor evolution. These alterations provide a useful explanation for the initial sensitivity of tumors to DNA-targeting chemotherapy. A striking example is dysfunctional homology-directed repair (HDR), e.g., due to inactivatin...
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| Vydáno v: | Front Oncol |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Frontiers Media S.A.
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7214843/ https://ncbi.nlm.nih.gov/pubmed/32432041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00670 |
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