Endothelial cells derived from patients' induced pluripotent stem cells for sustained factor VIII delivery and the treatment of hemophilia A

Hemophilia A (HA) is a bleeding disorder characterized by spontaneous and prolonged hemorrhage. The disease is caused by mutations in the coagulation factor 8 gene (F8) leading to factor VIII (FVIII) deficiency. Since FVIII is primarily produced in endothelial cells (ECs) in a non‐diseased human bei...

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Detalhes bibliográficos
Publicado no:Stem Cells Transl Med
Main Authors: Rose, Melanie, Gao, Kewa, Cortez‐Toledo, Elizabeth, Agu, Emmanuel, Hyllen, Alicia A., Conroy, Kelsey, Pan, Guangjin, Nolta, Jan A., Wang, Aijun, Zhou, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
Assuntos:
Pluripotent Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214661/
https://ncbi.nlm.nih.gov/pubmed/32162786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.19-0261
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