Potential long-term treatment of hemophilia A by neonatal co-transplantation of cord blood-derived endothelial colony-forming cells and placental mesenchymal stromal cells

BACKGROUND: Hemophilia A (HA) is an X-linked recessive disorder caused by mutations in the Factor VIII (FVIII) gene leading to deficient blood coagulation. As a monogenic disorder, HA is an ideal target for cell-based gene therapy, but successful treatment has been hampered by insufficient engraftme...

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Udgivet i:Stem Cell Res Ther
Main Authors: Gao, Kewa, Kumar, Priyadarsini, Cortez-Toledo, Elizabeth, Hao, Dake, Reynaga, Lizette, Rose, Melanie, Wang, Chuwang, Farmer, Diana, Nolta, Jan, Zhou, Jianda, Zhou, Ping, Wang, Aijun
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341603/
https://ncbi.nlm.nih.gov/pubmed/30670078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1138-8
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