Multiplex precise base editing in cynomolgus monkeys

Common polygenic diseases result from compounded risk contributed by multiple genetic variants, meaning that simultaneous correction or introduction of single nucleotide variants is required for disease modeling and gene therapy. Here, we show precise, efficient, and simultaneous multiplex base edit...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Wenhui, Aida, Tomomi, del Rosario, Ricardo C. H., Wilde, Jonathan J., Ding, Chenhui, Zhang, Xiaohui, Baloch, Zulqurain, Huang, Yan, Tang, Yu, Li, Duanduan, Lu, Hongyu, Zhou, Yang, Jiang, Minqing, Xu, Dongdong, Fang, Zhihao, Zheng, Zhanhong, Huang, Qunshan, Feng, Guoping, Yang, Shihua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214463/
https://ncbi.nlm.nih.gov/pubmed/32393762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16173-0
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