Multiplex precise base editing in cynomolgus monkeys

Common polygenic diseases result from compounded risk contributed by multiple genetic variants, meaning that simultaneous correction or introduction of single nucleotide variants is required for disease modeling and gene therapy. Here, we show precise, efficient, and simultaneous multiplex base edit...

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Pubblicato in:Nat Commun
Autori principali: Zhang, Wenhui, Aida, Tomomi, del Rosario, Ricardo C. H., Wilde, Jonathan J., Ding, Chenhui, Zhang, Xiaohui, Baloch, Zulqurain, Huang, Yan, Tang, Yu, Li, Duanduan, Lu, Hongyu, Zhou, Yang, Jiang, Minqing, Xu, Dongdong, Fang, Zhihao, Zheng, Zhanhong, Huang, Qunshan, Feng, Guoping, Yang, Shihua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214463/
https://ncbi.nlm.nih.gov/pubmed/32393762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16173-0
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