Multiplex precise base editing in cynomolgus monkeys

Common polygenic diseases result from compounded risk contributed by multiple genetic variants, meaning that simultaneous correction or introduction of single nucleotide variants is required for disease modeling and gene therapy. Here, we show precise, efficient, and simultaneous multiplex base edit...

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Vydáno v:Nat Commun
Hlavní autoři: Zhang, Wenhui, Aida, Tomomi, del Rosario, Ricardo C. H., Wilde, Jonathan J., Ding, Chenhui, Zhang, Xiaohui, Baloch, Zulqurain, Huang, Yan, Tang, Yu, Li, Duanduan, Lu, Hongyu, Zhou, Yang, Jiang, Minqing, Xu, Dongdong, Fang, Zhihao, Zheng, Zhanhong, Huang, Qunshan, Feng, Guoping, Yang, Shihua
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214463/
https://ncbi.nlm.nih.gov/pubmed/32393762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16173-0
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