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Characterization of a novel type III CRISPR-Cas effector provides new insights into the allosteric activation and suppression of the Cas10 DNase

Antiviral defense by type III CRISPR-Cas systems relies on two distinct activities of their effectors: the RNA-activated DNA cleavage and synthesis of cyclic oligoadenylate. Both activities are featured as indiscriminate nucleic acid cleavage and subjected to the spatiotemporal regulation. To yield...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Lin, Jinzhong, Feng, Mingxia, Zhang, Heping, She, Qunxin
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7214462/
https://ncbi.nlm.nih.gov/pubmed/32411384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-020-0160-4
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