Aptamer-functionalized Hybrid Nanoparticles to Enhance the Delivery of Doxorubicin into Breast Cancer Cells by Silencing P-glycoprotein

OBJECTIVE: The MDR of metastatic breast cancer cells is accompanied by the overexpression of P-gp transporter. This study has been focused to determine whether silencing the expression of P-gp by aptamer-labeled siRNA nanoparticles could enhance the delivery of doxorubicin into breast cancer cells i...

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Udgivet i:J Cancer Treatment Diagn
Main Authors: Chandra, Sruti, Michael Nguyen, Hoang, Wiltz, Kylar, Hall, Nicholas, Chaudhry, Shanzay, Olverson, George, Mandal, Tarun, Dash, Srikanta, Kundu, Anup
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213597/
https://ncbi.nlm.nih.gov/pubmed/32395707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.29245/2578-2967/2020/1.1176
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