Mitochondrial DNA Stress Signalling Protects the Nuclear Genome

The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. Thousands of copies of the circular mtDNA are present in most cell types that are packaged by...

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Publicado no:Nat Metab
Main Authors: Wu, Zheng, Oeck, Sebastian, West, A. Phillip, Mangalhara, Kailash C., Sainz, Alva G., Newman, Laura E., Zhang, Xiao-Ou, Wu, Lizhen, Yan, Qin, Bosenberg, Marcus, Liu, Yanfeng, Sulkowski, Parker L., Tripple, Victoria, Kaech, Susan M., Glazer, Peter M., Shadel, Gerald S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213273/
https://ncbi.nlm.nih.gov/pubmed/32395698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0150-8
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