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Phenomics-based quantification of CRISPR-induced mosaicism in zebrafish

Genetic mosaicism can manifest as spatially variable phenotypes that vary from site-to-site within an organism. Here, we use imaging-based phenomics to quantitate phenotypes at many sites within the axial skeleton of CRISPR-edited G0 zebrafish. Through characterization of loss-of-function cell clust...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Watson, Claire J., Monstad-Rios, Adrian T., Bhimani, Rehaan M., Gistelinck, Charlotte, Willaert, Andy, Coucke, Paul, Hsu, Yi-Hsiang, Kwon, Ronald Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213258/
https://ncbi.nlm.nih.gov/pubmed/32191876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.02.007
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