MPC-11 IDH1/2 MUTATIONS ARE ASSOCIATED WITH SEIZURE ONSET AND VETRY IMAGING IN PATIENTS WITH DIFFUSE GLIOMA VISUALIZING 2-HYDROXYGLUTARATE BY MASS SPECTRUM

BACKGROUND: Mutations in isocitrate dehydrogenase 1 or 2 genes (IDH1/2) frequently occur in lower-grade gliomas. Mutant IDH1/2 proteins gain a new ability to produce 2-hydroxyglutarate (2HG). IDH1/2 mutations have shown to be related with seizure through the structural similarity of 2HG to glutamate...

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Published in:Neurooncol Adv
Main Authors: Ohno, Makoto, Hayashi, Mitsuhiro, Aikawa, Hiroaki, Matsushita, Yuko, Miyakita, Yasuji, Takahashi, Masamichi, Ichimura, Koichi, Hamada, Akinobu, Narita, Yoshitaka
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213130/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz039.107
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