NCMP-09. ISOCITRATE DEHYDROGENASE MUTATIONS AND INCREASED TISSUE 2-HYDROXYGLUTARATE CONCENTRATION MIGHT BE RELATED WITH SEIZURE ONSET IN PATIENTS WITH GLIOMAS

Mutations in isocitrate dehydrogenase 1 or 2 genes (IDH1/2) frequently occur in lower-grade gliomas and secondary glioblastomas. Mutant IDH1/2 proteins gain a new ability to produce the oncometabolite 2-hydroxyglutarate (2HG). Recently, IDH1/2 mutations were suggested to be related with seizure onse...

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Publicat a:Neuro Oncol
Autors principals: Ohno, Makoto, Hayashi, Mitsuhiro, Matsushita, Yuko, Miyakita, Yasuji, Takahashi, Masamichi, Yamazawa, Erika, Tsushita, Natsuko, Ichimura, Koichi, Hamada, Akinobu, Narita, Yoshitaka
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216700/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.809
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