N(6)-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

N(6)-methyladenosine (m(6)A) regulates stability and translation of messenger RNA (mRNA) in various biological processes. In this work, we show that knockout of the m(6)A writer Mettl3 or the nuclear reader Ythdc1 in mouse embryonic stem cells increases chromatin accessibility and activates transcri...

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Publicat a:Science
Autors principals: Liu, Jun, Dou, Xiaoyang, Chen, Chuanyuan, Chen, Chuan, Liu, Chang, Xu, Meng Michelle, Zhao, Siqi, Shen, Bin, Gao, Yawei, Han, Dali, He, Chuan
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213019/
https://ncbi.nlm.nih.gov/pubmed/31949099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay6018
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