N(6)-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

N(6)-methyladenosine (m(6)A) regulates stability and translation of messenger RNA (mRNA) in various biological processes. In this work, we show that knockout of the m(6)A writer Mettl3 or the nuclear reader Ythdc1 in mouse embryonic stem cells increases chromatin accessibility and activates transcri...

Full description

Saved in:
Bibliographic Details
Published in:Science
Main Authors: Liu, Jun, Dou, Xiaoyang, Chen, Chuanyuan, Chen, Chuan, Liu, Chang, Xu, Meng Michelle, Zhao, Siqi, Shen, Bin, Gao, Yawei, Han, Dali, He, Chuan
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213019/
https://ncbi.nlm.nih.gov/pubmed/31949099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay6018
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items