N(6)-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

N(6)-methyladenosine (m(6)A) regulates stability and translation of messenger RNA (mRNA) in various biological processes. In this work, we show that knockout of the m(6)A writer Mettl3 or the nuclear reader Ythdc1 in mouse embryonic stem cells increases chromatin accessibility and activates transcri...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Liu, Jun, Dou, Xiaoyang, Chen, Chuanyuan, Chen, Chuan, Liu, Chang, Xu, Meng Michelle, Zhao, Siqi, Shen, Bin, Gao, Yawei, Han, Dali, He, Chuan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213019/
https://ncbi.nlm.nih.gov/pubmed/31949099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay6018
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