N(6)-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

N(6)-methyladenosine (m(6)A) regulates stability and translation of messenger RNA (mRNA) in various biological processes. In this work, we show that knockout of the m(6)A writer Mettl3 or the nuclear reader Ythdc1 in mouse embryonic stem cells increases chromatin accessibility and activates transcri...

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Udgivet i:Science
Main Authors: Liu, Jun, Dou, Xiaoyang, Chen, Chuanyuan, Chen, Chuan, Liu, Chang, Xu, Meng Michelle, Zhao, Siqi, Shen, Bin, Gao, Yawei, Han, Dali, He, Chuan
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7213019/
https://ncbi.nlm.nih.gov/pubmed/31949099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay6018
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