A neuroglobin-based high-affinity ligand trap reverses carbon monoxide–induced mitochondrial poisoning

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and...

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Опубликовано в: :J Biol Chem
Главные авторы: Rose, Jason J., Bocian, Kaitlin A., Xu, Qinzi, Wang, Ling, DeMartino, Anthony W., Chen, Xiukai, Corey, Catherine G., Guimarães, Danielle A., Azarov, Ivan, Huang, Xueyin N., Tong, Qin, Guo, Lanping, Nouraie, Mehdi, McTiernan, Charles F., O'Donnell, Christopher P., Tejero, Jesús, Shiva, Sruti, Gladwin, Mark T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2020
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212636/
https://ncbi.nlm.nih.gov/pubmed/32205448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010593
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