A neuroglobin-based high-affinity ligand trap reverses carbon monoxide–induced mitochondrial poisoning

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and...

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Udgivet i:J Biol Chem
Main Authors: Rose, Jason J., Bocian, Kaitlin A., Xu, Qinzi, Wang, Ling, DeMartino, Anthony W., Chen, Xiukai, Corey, Catherine G., Guimarães, Danielle A., Azarov, Ivan, Huang, Xueyin N., Tong, Qin, Guo, Lanping, Nouraie, Mehdi, McTiernan, Charles F., O'Donnell, Christopher P., Tejero, Jesús, Shiva, Sruti, Gladwin, Mark T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212636/
https://ncbi.nlm.nih.gov/pubmed/32205448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010593
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