A neuroglobin-based high-affinity ligand trap reverses carbon monoxide–induced mitochondrial poisoning

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Rose, Jason J., Bocian, Kaitlin A., Xu, Qinzi, Wang, Ling, DeMartino, Anthony W., Chen, Xiukai, Corey, Catherine G., Guimarães, Danielle A., Azarov, Ivan, Huang, Xueyin N., Tong, Qin, Guo, Lanping, Nouraie, Mehdi, McTiernan, Charles F., O'Donnell, Christopher P., Tejero, Jesús, Shiva, Sruti, Gladwin, Mark T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212636/
https://ncbi.nlm.nih.gov/pubmed/32205448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010593
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