α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cell...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Morgan, Sophie A., Lavenir, Isabelle, Fan, Juan, Masuda-Suzukake, Masami, Passarella, Daniela, DeTure, Michael A., Dickson, Dennis W., Ghetti, Bernardino, Goedert, Michel
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212628/
https://ncbi.nlm.nih.gov/pubmed/32209651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012179
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