Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia

BACKGROUND: Acute promyeloid leukemia (APL) is characterized by the oncogenic fusion protein PML-RARα, a major etiological agent in APL. However, the molecular mechanisms underlying the role of PML-RARα in leukemogenesis remain largely unknown. RESULTS: Using an inducible system, we comprehensively...

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Dades bibliogràfiques
Publicat a:Genome Biol
Autors principals: Wang, Ping, Tang, Zhonghui, Lee, Byoungkoo, Zhu, Jacqueline Jufen, Cai, Liuyang, Szalaj, Przemyslaw, Tian, Simon Zhongyuan, Zheng, Meizhen, Plewczynski, Dariusz, Ruan, Xiaoan, Liu, Edison T., Wei, Chia-Lin, Ruan, Yijun
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212609/
https://ncbi.nlm.nih.gov/pubmed/32393309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02030-2
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