High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma

Glioblastoma (GBM), the deadliest form of brain cancer, presents long-standing problems due to its localization. Chimeric antigen receptor (CAR) T cell immunotherapy has emerged as a powerful strategy to treat cancer. IL-13-receptor-α2 (IL13Rα2), present in over 75% of GBMs, has been recognized as a...

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Detalhes bibliográficos
Publicado no:Bioact Mater
Main Authors: Kim, Gloria B., Aragon-Sanabria, Virginia, Randolph, Lauren, Jiang, Hali, Reynolds, Joshua A., Webb, Becky S., Madhankumar, Achuthamangalam, Lian, Xiaojun, Connor, James R., Yang, Jian, Dong, Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Publishing 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212185/
https://ncbi.nlm.nih.gov/pubmed/32405577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioactmat.2020.04.011
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