Chromosome errors in human eggs shape natural fertility over reproductive lifespan

Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions causing pregnancy loss and congenital disorders. Here we have followed chromosome segregation in human oocytes from females aged 9 to 43 years, and report that aneuploidy follows a U-curve. Specific segregatio...

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Publicado no:Science
Main Authors: Gruhn, Jennifer R., Zielinska, Agata P., Shukla, Vallari, Blanshard, Robert, Capalbo, Antonio, Cimadomo, Danilo, Nikiforov, Dmitry, Chan, Andrew Chi-Ho, Newnham, Louise J., Vogel, Ivan, Scarica, Catello, Krapchev, Marta, Taylor, Deborah, Kristensen, Stine Gry, Cheng, Junping, Ernst, Erik, Bjørn, Anne-Mette Bay, Colmorn, Lotte Berdiin, Blayney, Martyn, Elder, Kay, Liss, Joanna, Hartshorne, Geraldine, Groendahl, Marie Louise, Rienzi, Laura, Ubaldi, Filippo, McCoy, Rajiv, Lukaszuk, Krzysztof, Andersen, Claus Yding, Schuh, Melina, Hoffmann, Eva R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212007/
https://ncbi.nlm.nih.gov/pubmed/31604276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav7321
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